An MBoC Favorite: Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte
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An MBoC Favorite: Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte
The Caenorhabditis elegans oocyte is a highly amenable system for forward and reverse genetic analysis of receptor-mediated endocytosis. We describe the use of transgenic strains expressing a vitellogenin::green fluorescent protein (YP170::GFP) fusion to monitor yolk endocytosis by the C. elegans oocyte in vivo. This YP170::GFP reporter was used to assay the functions of C. elegans predicted pr...
متن کاملReceptor-mediated Endocytosis in the Caenorhabditis elegans Oocyte
The Caenorhabditis elegans oocyte is a highly amenable system for forward and reverse genetic analysis of receptor-mediated endocytosis. We describe the use of transgenic strains expressing a vitellogenin::green fluorescent protein (YP170::GFP) fusion to monitor yolk endocytosis by the C. elegans oocyte in vivo. This YP170::GFP reporter was used to assay the functions of C. elegans predicted pr...
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Members of the MKLP1 subfamily of kinesin motor proteins localize to the equatorial region of the spindle midzone and are capable of bundling antiparallel microtubules in vitro. Despite these intriguing characteristics, it is unclear what role these kinesins play in dividing cells, particularly within the context of a developing embryo. Here, we report the identification of a null allele of zen...
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I dare say that a total of 72 graduate school and medical school classes over the past 31/2 years, since beginning the M.D.-Ph.D., Program has rendered me qualified to comment on upper-level science education. During that time I have been taught by every technique ever invented, and my performance has been evaluated in every way imaginable. The good news is that, for the most part, my teachers ...
متن کاملAn MBoC Favorite: Regulation of the vitellogenin receptor during Drosophila melanogaster oogenesis
Unlike mosquitoes, which produce yolk-loaded eggs only after a blood meal, Drosophila egg production is not invariantly coupled to nutrition. Before this study, precisely why the immature egg stages do not accumulate yolk by endocytosis was unknown. By following the expression patterns of the Drosophila transmembrane vitellogenin receptor, Yolkless, the authors found transcripts and receptor pr...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2012
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e12-02-0143